1141 PATHOGENESIS OF TOXIC SHOCK SYNDROME (TSS)

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Toxic Shock Syndrome (TSS)

Toxic Shock Syndrome, otherwise known as TSS, is a systemic infection that is associated with the bacteria Staphylococcus aureus [1]. S. aureus exists as part of the human body’s normal bacteria, and does not cause infection since most people develop antibodies against the bacteria. Infection can be result in people that have not developed these antibodies, or may develop in people that have an...

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Protection of rabbits in an infection model of toxic shock syndrome (TSS) by a TSS toxin-1-specific monoclonal antibody.

An anti-TSST-1-specific monoclonal antibody (MAb 8-5-7) was tested for its protective capacity in a rabbit infection model to toxic shock syndrome (TSS). The challenge strain of Staphylococcus aureus (RN4710), which contained a plasmid encoding TSS toxin-1, was introduced into previously implanted chambers. Purified monoclonal antibody (1.25 mg of immunoglobulin G) administered parenterally 1 d...

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Toxic shock syndrome

Toxic shock syndrome is an acute febrile illness with mucocutaneous manifestations and multisystem involvement, often associated with focal staphylococcal infection. Although Todd originally described the disorder in children,' with a subsequent report of childhood toxic shock syndrome,2 publicity given to the disorder in relation to menstruation and tampon use has resulted in its being conside...

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Toxic shock syndrome.

The entity of the variable pictures of an illness summed up by the description "toxic shock syndrome" has been focussed on by a great number of publications in Northern America since 1978, but has been described scarcely until yet in Germany. An etiological relationship with formerly described "toxic scarlet fever" and "Kawasaki syndrome" is to be discussed. This case in charge deals with a 25-...

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Toxic-shock syndrome.

In the past 10 years, we have learned much about TSS and S. aureus and its toxins. A number of important biologic principles have been reemphasized in this first decade of TSS research: S. aureus is a very complex organism, one not likely to yield quick answers; in vitro observations must always be confirmed in the patient; animal models may not always be reliable replicates of human disease; a...

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 1985

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-198504000-01171